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Link to book1 months ago
Saving VCFs to artifacts and back again1 months ago
Overview | Quick start | Session information
Saving SingleCellExperiments to artifacts and back again1 months ago
Overview | Quick start | Session information
Flexible clustering for Bioconductor2 months ago
Introduction | Based on distance matrices | Hierarchical clustering | Affinity propagation | With a fixed number of clusters | $k$-means clustering | Self-organizing maps | Graph-based clustering | Density-based clustering | Two-phase clustering | Obtaining full clustering statistics | Further comments | Session information
Assorted clustering diagnostics2 months ago
Introduction | Computing the silhouette width | Computing the neighborhood purity | Computing per-cluster RMSD | Computing graph modularity | Comparing two clusterings | Bootstrapping cluster stability | Clustering parameter sweeps | Linking clusters | Comparing multiple clusterings | Session information
Link to book2 months ago
Gene set searches with the Gesel database4 months ago
Introduction | Quick start | Using low-level functions | Finding overlaps | Searching on text | Fetching all data | Flushing the cache | Customizing the database | Creating the custom database | Reading custom files | Contributing custom sets | Session information
Differential expression analysis pipelines6 months ago
Overview | Quick start | More experimental designs | More comparison types | Subsetting samples | More output options | Session information
Simple single-cell analyses6 months ago
Overview | Quick start | Multi-batch analyses | With proteomics | Cell type annotation | Session information
Using scran to analyze single-cell RNA-seq data6 months ago
Introduction | Quick clustering | Automated PC choice | Detecting correlated genes | Session information
Legacy utilities for single-cell RNA-seq analysis6 months ago
Introduction | Computing feature-level statistics | Making gene symbols unique | Creating a data.frame | Scaling normalization | Median-based normalization | Pooling normalization | Spike-in normalization | Session information
Book for scrapper8 months ago
Finding neighbors in high-dimensional space9 months ago
Overview | Finding nearest neighbors | Finding all neighbors within range | Saving indices to disk | Usage in downstream C++ libraries | Extending to new methods | Introduction | In R | In C++ | Session information
Gene set enrichment pipelines9 months ago
Overview | Quick start | Considering directionality | Differential gene set tests | More output options | Session information
Differential barcode abundance for functional screens9 months ago
Overview | Quick start | Explaining parameters | Gene-level statistics | More output options | Session information
Automatic generation of analysis reports9 months ago
Introduction | Quick start | Writing the template | Representing data inputs | Computing results | Session information
Packaging the igraph C library10 months ago
Overview | Quick start | For R administrators | Session information
Bioconductor-managed conda installation11 months ago
Overview | For package developers | Setting defaults | Historical comments | Session information
Developing packages with beachmat1 years ago
Overview | Linking instructions | Reading matrix data | Enabling parallelization | Comparison to block processing | Session information
Freezing Python versions inside Bioconductor packages1 years ago
Overview | For package developers | Setting up the package | Specifying Python environments | Defining BasiliskEnvironment objects | Populating environments on installation | Using the environments | Basics | Function constraints | Persisting variables across calls | For end users | Troubleshooting known issues | Fine-tuning basilisk's behavior | Using basilisk directly for analyses | Session information
Cmake for Bioconductor1 years ago
Overview | Worked example | Setting defaults | Session information
Saving objects to artifacts and back again2 years ago
Introduction | Quick start | Class-specific methods | Operating on directories | Extending to new classes | Creating applications | Session information
Saving arrays to artifacts and back again2 years ago
Overview | Quick start | Saving delayed operations | Session information
Managing expiration of versioned subdirectories2 years ago
Background | Setting the access time | Maintaining thread safety | Deleting old caches | Session information
Save/load spatial omics data to/from file2 years ago
Overview | Quick start | Session info
Using TileDB-backed matrices with beachmat2 years ago
Overview | For users | For developers | Session information
Using HDF5-backed matrices with beachmat2 years ago
Overview | For users | For developers | In-memory caching | Session information
Saving and reloading DelayedArray objects2 years ago
Motivation | Quick start | More interesting seeds | Session information
Detecting differentially abundant subpopulations in mass cytometry data2 years ago
Introduction | Setting up the data | Mocking up a data set | Pre-processing of intensities | Pooling cells together | Estimating transformation parameters | Gating out uninteresting cells | Applying functions to the original data | Normalizing intensities across batches | Counting cells into hyperspheres | Testing for significant differences in abundance | Controlling the spatial FDR | Visualizing and interpreting the results | With static plots | Using a Shiny app | Additional notes | Session information
Counting barcodes in sequencing screens2 years ago
Overview | Counting single barcodes | Counting combinatorial barcodes | Counting dual barcodes | Counting dual barcodes (single-end) | Counting random barcodes | Further options | Supporting mismatches | Searching the other strand | Parallelization across files | Session information
Assortment of header-only libraries2 years ago
Overview | Quick start | Available libraries | Using interfaces | Contributing
Saving SummarizedExperiments to artifacts and back again2 years ago
Overview | Quick start | Session information
Using the ResidualMatrix class2 years ago
Overview | Using the ResidualMatrix | Retaining certain factors | Restricting observations | Session information
Interacting with the gypsum REST API3 years ago
Introduction | Reading files | Uploading files | Basic usage | Link generation | Changing permissions | Probational uploads | Inspecting the quota | Validating metadata | Administration | Session information
Utilities for multi-modal single-cell analyses3 years ago
Overview | Setting up the dataset | Rescaling by neighbors | Intersecting clusters | Multi-metric UMAP | Intersecting graphs | Correlation analyses | Session information
Pokédex for Cell Types3 years ago
Overview | Finding references | General-purpose references | Human primary cell atlas (HPCA) | Blueprint/ENCODE | Mouse RNA-seq | Immune references | Immunological Genome Project (ImmGen) | Database of Immune Cell Expression/eQTLs/Epigenomics (DICE) | Novershtern hematopoietic data | Monaco immune data | Adding new references | Session information | References
Overview of the scRNAseq dataset collection3 years ago
Introduction | Finding datasets | Loading a dataset | Adding new datasets | Session information
Saving BumpyMatrices to file3 years ago
Overview | Saving a BumpyMatrix | Loading a BumpyMatrix | Session info
Saving common bioinformatics file formats3 years ago
Overview | Quick start | Integration with other objects | Validation | Session information
Saving XStringSets to artifacts and back again3 years ago
Overview | Quick start | Quality scaled strings | Session information
Saving MultiAssayExperiments to artifacts and back again3 years ago
Overview | Quick start | Session information
Saving genomic ranges to artifacts and back again3 years ago
Overview | Quick start | Further comments | Session information
Using the ScaledMatrix class3 years ago
Overview | Matrix multiplication | Other utilities | Caveats | Session information
Umbrella for the alabaster framework4 years ago
Motivation | Session information
Metadata schemas for Bioconductor objects4 years ago
Link to book4 years ago
Meta-analyses on p-values of various differential tests5 years ago
Overview | Meta-analyses on $p$-values | $p$-value combining strategies | Summarizing the direction | Further comments | Session information
DelayedArrays of random values5 years ago
Introduction | Available distributions | Chunking | Further comments | Session information
Classes for genomic interaction data5 years ago
Introduction | Description of the GInteractions class | Construction | Getters | Setters | Subsetting and combining | Sorting, duplication and matching | Distance calculations | Overlap methods | Linking sets of regions | Finding the bounding box | Enforcing anchor ordering in StrictGInteractions | Description of the InteractionSet class | Other methods | Description of the ContactMatrix class | Sorting and duplication | Distance calculation | Converting between classes | Inflating a GInteractions into a ContactMatrix | Deflating a ContactMatrix into an InteractionSet | Linearizing an InteractionSet into a RangedSummarizedExperiment | Summary
Correcting batch effects in single-cell RNA-seq data6 years ago
Introduction | Setting up demonstration data | Function organization | Mutual nearest neighbors | Overview | The new, fast method | The old, classic method | The cluster-based method | Batch rescaling | Using data subsets | Selecting genes | Restricted correction | Other utilities | Multi-batch normalization | Multi-batch PCA | Session information | References
Link to book6 years ago
Matrix representations to support decomposition6 years ago
Overview | The DeferredMatrix class | The LowRankMatrix class | The ResidualMatrix class | Session information
Using BumpyMatrix objects6 years ago
Overview | Construction | Basic operations | Advanced subsetting | Additional operations | Session information
Trajectory utilities for package developers6 years ago
Overview | MST construction | Operations on the MST | The PseudotimeOrdering class | Session information
Introducing the csaw package6 years ago
Introduction | Documentation | Session information
Using Bioconductor to detect differential binding in ChIP-seq data6 years ago
Redirection notice
Detecting differential enrichment of H3K9ac in murine B cells6 years ago
Redirection notice
Detecting differential binding of CBP in mouse fibroblasts6 years ago
Redirection notice
Detecting differential enrichment of H3K27me3 in the mouse lung epithelium6 years ago
Redirection notice
User's guide6 years ago
Processing statistics for ChIP-seq datasets6 years ago
Introduction | Obtaining each dataset | Investigating mapping statistics | Session information | References
Test files for utilities to process droplet-based single cell data6 years ago
Motivation | Functions | Example | Session information
A DelayedArray backend for TileDB6 years ago
Introduction | Creating a TileDBArray | Manipulating TileDBArrays | Controlling backend creation | Session information
Extending dispatch to more batch correction methods7 years ago
Overview | Setting up | Deriving a BatchelorParam subclass | Defining a batchCorrect method | Input | Output | Demonstration | Session information
Singular value decomposition for Bioconductor packages8 years ago
Overview | Taking the cross-product | Centering and/or scaling | Other SVD-related options | Running the PCA | Session information